BOTOX® Cosmetic is contraindicated in the presence of infection at the proposed injection site(s) and in individuals with known hypersensitivity to any ingredient in the formulation. Do not exceed the recommended dosage and frequency of administration of BOTOX® Cosmetic. Patients with neuromuscular disorders may be at increased risk of clinically significant systemic effects including severe dysphagia and respiratory compromise from typical doses of BOTOX® Cosmetic.
Treatment with BOTOX® Cosmetic for cosmetic purposes may result in the formation of antibodies that may reduce the effectiveness of subsequent treatments with BOTOX® Cosmetic for glabellar lines or other indications. However rare, the potential for antibody formation may be minimized by injecting with the lowest effective dose given with the longest feasible intervals between injections.